Vegetarian Source of Essential Fats

In the first study to investigate the effect of the omega-3 DHA (docosahexaneoic acid) derived from algae, researchers found that people suffering from age-related decline in their thinking (cognition) could get a memory boost by supplementing with the extract.
DHA is a fatty acid found in high concentrations in some fish. Together with other fish-derived oils, DHA is believed to help slow the rate of cognitive decline in people with mild impairment, but it has never been studied on its own.
As the world’s population continues to age, health issues related to aging bodies and brains are becoming more common. Many population-based studies have noted the association between lower DHA levels and cognitive decline in healthy people and those with Alzheimer’s disease.
According to the journal Alzheimer’s and Dementia, the new study was led by doctors at Martek Biosciences Corporation, the company that manufactures the algal DHA supplement used in this study. A total of 437 people aged 55 or older with age-related cognitive decline completed the 24-week study. Half of them were given 900 mg per day of DHA from the algae, Schizochytrium sp.; the rest were given a matching placebo.
Tests were given before and after the supplementation period to measure memory, learning, attention, problem solving, and skills involved with decision making and abstract thinking (executive function skills).
Anti-aging for the brain
The ability to recollect past experiences (episodic memory) and learning in the DHA group significantly improved. People with lower scores at the study outset seemed to benefit the most, as did those with a family history of dementia and those taking cholesterol-lowering medications, “suggesting that potential genetic and cardiovascular factors may influence the effects of DHA on cognition,” the team commented. There was also a significant decrease in heart rate associated with DHA supplementation.
Working memory–that which is used to store and manage information–was not affected, nor was executive function. Participants reported no adverse side effects related to treatment.
Use it, don’t lose it
Try these tips to help keep your mind spry.
• Get moving. Physical exercise helps keep the mind and body young by protecting brain tissue from age-related damage and by keeping the heart healthy.
• Stay involved. People who connect with others through church, volunteering, travel, and leisure activities are doing their brains a favor. Staying socially engaged reduces stress and helps keep the mind sharp.
• Eat right. Diets rich in brightly-colored fruits and vegetables and lean protein (especially fish) help ward off brain-damaging free radicals, preserving tip top brain function.
 (Alzheimers Dement 2010;456-64)

Cognitive Impairment and B Vitamins

Daily tablets of large doses of vitamins can halve the rate of brain shrinkage in elderly people with memory problems and may slow their progression toward dementia, data from a recent British trial showed.

Scientists from Oxford University said their two-year clinical trial was the largest to date into the effect of B vitamins on so-called “mild cognitive impairment” — a major risk factor for Alzheimer’s disease and other forms of dementia.

Experts commenting on the findings said they were important and called for larger, longer full-scale clinical trials to see if the safety and effectiveness of B vitamins in the prevention of neurodegenerative conditions could be confirmed.

“Th
is is a very dramatic and striking result. It’s much more than we could have predicted,” said David Smith of Oxford’s department of pharmacology, who co-led the trial.

“It is our hope that this simple and safe treatment will delay development of Alzheimer’s in many people who suffer from mild memory problems.”

Mild cognitive impairment (MCI) affects around 16 percent of people aged over 70 worldwide and is characterized by slight problems with memory loss, language or other mental functions.

MCI does not usually interfere with daily life, but around 50 percent of people diagnosed with it go on to develop the far more severe Alzheimer’s disease within five years. Alzheimer’s is a mind-wasting disease for which there are few treatments and no cure, and which affects 26 million people around the world.

Smith and colleagues conducted a two-year trial with 168 volunteers with MCI who were given either a vitamin pill containing very high doses of folic acid, vitamin B6 and vitamin B12, or a placebo dummy pill.

These B vitamins are known to control levels of an amino acid called homocysteine in the blood, and high blood levels of homocysteine are linked to an increased risk of developing Alzheimer’s disease.

Brain scans were taken at the beginning and the end of the trial to monitor the rate of brain shrinkage, or atrophy.

The results, published in the Public Library of Science (PLoS) One journal, showed that on average the brains of those taking the vitamin treatment shrank at a rate of 0.76 percent a year, while those taking the dummy pill had an average brain shrinkage of 1.08 percent.

People who had the highest levels of homocysteine at the start of the trial benefited the most from the treatment, with their brains shrinking at half the rate of those on the placebo.

Although the trial was not designed to measure cognitive ability, the researchers found those people who had lowest rates of shrinkage had the highest scores in mental tests.

Dementia and Vitamin E

The July 2010 edition of Archives of Neurology contains a study that demonstrates an inverse relationship between vitamin E intake and dementia risk, including Alzheimer’s. Participants in the study were followed for roughly a decade, and those who had the highest dietary intake of Vitamin E were shown to have the lowest incidence of dementia. Overall, higher vitamin E intake was linked to a 25% reduction in dementia risk.

Food sources of vitamin E include wheat germ, spinach, broccoli, almonds, and hazelnuts. Although this study didn’t take vitamin E supplementation into consideration, you still may want to consider supplementing with 200 IU of natural, mixed-tocopherol on a daily basis for optimal health benefits.